Lipocalin 2 (Lipocalin-2, Lcn2, 24p3, 25kD alpha-2-microglobulin-related Subunit of MMP-9, HNL, MSFI, Neutrophil Gelatinase-associated Lipocalin, NGAL, Oncogene 24p3, p25) (Biotin)

Catalogue Number: L2499-15P-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a lyophilized powder in PBS, BSA. Reconstitute with sterile TBS, pH7.3 (20mM Trizma base, 150mM sodium chloride), 0.1% BSA to 500ug/ml. Labeled with Biotin.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	24p3\|25 kDa alpha-2-microglobulin-related subunit of MMP-9\|migration-stimulating factor inhibitor\|MSFI\|neutrophil gelatinase-associated lipocalin\|NGAL\|oncogene 24p3\|p25\|siderocalin LCN2
Shipping Condition:	Blue Ice
Unit(s):	250 ug
Host name:	Rat
Clone:	11n126
Isotype:	IgG2a
Immunogen:	Recombinant corresponding to Gln21-Asn200 from mouse Lipocalin-2 expressed in NSO cells.
Application:	ELISA

Overview
Datasheets

Description

Description: Mouse Lipocalin-2 was cloned from mouse kidney cells (1). Its very high level of expression at the post-stratum uterus gave it the name uterocalin (2). Lipocalin-2 has been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis (3-5). Studies indicate that Lipocalin-2 binds a bacterial catecholate siderophore that is bound to a ferric ion, such as enterobactin, with a subnanomolar dissociation constant (KD = 0.41 nM) (6). The bound ferric enterobactin complex breaks down slowly in a month into dihydroxybenzoyl serine and dihydroxybenzoic acid (DHBA). It also binds to a ferric DHBA complex with much less KD values (7.9 nM) (6). Secretion of Lipocalin-2 in immune cells increases in response to stimulation of Toll-like receptor as an acute phase response to infection. As a result, it acts as a potent bacteriostatic reagent by sequestering iron (7). Moreover, Lipocalin-2 can alter the invasive and metastatic behavior of Ras-transformed breast cancer cells in vitro and in vivo by reversing the epithelial to mesenchymal transition inducing activity of Ras, through restoration of E-cadherin expression, via effects on the Ras-MAPK signaling pathway (8).

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

LCN2

Uniprot ID

P80188

Gene ID

3934

Specificity

Recognizes mouse Lipocalin-2. No cross-reactivity or interference with recombinant human Lipocalin-1, rhLipocalin-2, or recombinant rat Lipocalin-2.

Purification

Protein G purified

Antibody Clonality

Monoclonal

L2499-15P Datasheet

Price

£922.00

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