LRP5 (Low-density Lipoprotein Receptor-related Protein 5, LRP-5, LRP7)

Catalogue Number: L2601-05Z-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, <0.02% sodium azide, 50% glycerol.
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rabbit
Clone:	D80F2
Isotype:	IgG
Immunogen:	Recombinant protein specific to the C-terminus of human LRP5.
Application:	IP, WB

Overview
Datasheets

Description

Description: LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density-lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain and proline-rich motifs in the cytoplasmic domain (1). They function as co-receptors for Wnt and are required for the canonical Wnt/B-catenin signaling pathway (2,3). LRP5 and LRP6 are highly homologous and have redundant roles during development (4,5). The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins (6,7). Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 (8-10). The phosphorylated LRP6 recruits axin to the membrane, and presumably activates B-catenin signaling (8-10). LRP5 is involved in the regulation of bone homeostasis. Mutations and polymorphisms in LPR5 are associated with bone diseases like osteoporosis-pseudoglioma syndrome and high-bone-mass disorders (11-13). In addition, mutations in LRP5 are found in patients with hyperparathyroid tumor and breast cancer (14,15).

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

LRP5

Uniprot ID

O75197

Specificity

Recognizes endogenous levels of total human LRP5. Species Crossreactivity: Mouse and rat.

Gene ID

4041

Purification

Purified

Antibody Clonality

Monoclonal

L2601-05Z Datasheet

Price

£592.00

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