Ly49C,F,H,I (Biotin)
Catalogue Number: L7732-01B-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with Biotin. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Hamster |
| Clone: | 14B11 |
| Isotype: | IgG |
| Immunogen: | |
| Application: | FC |
Description
Description: Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated.2 These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The antibody stains ~ 90% of NK1.1+CD3- splenocytes, and ~ 6% of CD8+ spleen cells from C57BL/6 mice.1 The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Recognizes an epitope common to the Ly49C, Ly49F, Ly49H and Ly49I allelic/splice variants. Reacts with murine Ly49C, Ly49F, Ly49H and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors.
Purification
Purified
Antibody Clonality
Monoclonal
L7732-01B Datasheet
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