Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA) (PE/CY5)

Catalogue Number: L9190-09E-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 0.09% sodium azide and a stabilizing agent. Labeled with PE/CY5.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	5K76 (H4A3)
Isotype:	IgG1, kappa
Immunogen:	Human adherent peripheral blood cells
Application:	FC, IHC

Overview
Datasheets

Description

Description: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

LAMP1

Gene ID

3916

Uniprot ID

P11279

Specificity

Recognizes human LAMP 1.

Purification

Purified

Antibody Clonality

Monoclonal

L9190-09E Datasheet

Price

£548.00

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