EIF2B5 Antibody (phospho-Ser539)
Catalogue Number: LS-C23313-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Preservative: | 0.1% sodium azide |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | EIF2B5, CACH, EIF2BE, EIF-2B, LVWM, CLE, EIF2Bepsilon |
| Shipping Condition: | RT |
| Unit(s): | 10 blots |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | |
| Immunogen: | Synthetic phosphopeptide derived from the region of rat eIF2B that contains serine 535 (corresponding to serine 539 in the human sequence). |
| Application: | WB, FA |
Additional Text
Gene Name
EIF2B5
Purification
Affinity Purified
Gene ID
8893
Antigen Type
Synthetic Phosphopeptide
Short Description
EIF2B5 antibody LS-C23313 is an unconjugated rabbit polyclonal antibody to EIF2B5 (pSer539) from human. It is reactive with human and rat. Validated for Func and WB.
Antibody Clonality
Polyclonal
Modification
Phosphorylated, Ser539
Application Notes
The antibody has been used in Western blotting. Eukaryotic Initiation Factor 2B (eIF2B) plays a key role in the initiation of mRNA translation in eukaryotic cells by acting as a guanine nucleotide exchange factor. The activity of eIF2B is regulated by a wide array of conditions. Stress inhibits its action, while stimulation of protein synthesis results in its activation. eIF2B, an 82kD subunit of eIF2B, is phosphorylated at serine 539 by glycogen synthase kinase-3 (GSK-3), which leads to inhibition of its guanine nucleotide exchange activity. Positive control: Recombinant eIF2B treated with GSK-3 ; CHO-T cells transfected with human insulin receptor (IR) +/- insulin.
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