Melanoma Antibody (clone PNL2, Azide-free, BSA-free)

Catalogue Number: LS-C391415-LSP

Manufacturer:	LifeSpan BioSciences Inc.
Shelf Life:	24 months
Preservative:	Azide-free
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	RT
Storage Condition:	2-8°C
Unit(s):	100 ug
Host name:	Mouse
Clone:	PNL2
Isotype:	IgG1
Immunogen:	Melanocyte antigen.
Application:	IF, IHC-P, IHC

Overview

Additional Text

Concentration

0.5 mg/ml

Purification

Protein G purified

Short Description

Melanoma antibody LS-C391415 is an unconjugated mouse monoclonal antibody to human Melanoma. Validated for IF and IHC.

Antibody Clonality

Monoclonal

Storage Note

Store at 2°C to 8°C.

Application Notes

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF. Optimal dilution of the Melanoma antibody PNL2 should be determined by the researcher. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.

Price

£714.00

-

Quantity
Unit Size

Find out about delivery