Human CD4 Protein (Recombinant)

Catalogue Number: LS-G133780-LSP

Manufacturer:	LifeSpan BioSciences Inc.
Shelf Life:	30 months
Molecular Weight:	41.3 kDa or 45-55 kDa
Physical state:	Lyophilized
Type:	Other Recombinant Protein
Alias:	CD4, CD4 antigen, CD4 receptor, CD4mut, CD4 antigen (p55), CD4 molecule
Host Cell:	CHO Cells
Shipping Condition:	RT
Unit(s):	10 ug, 50 ug

Overview

Description

Description: Cluster determinant 4 (CD4), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction and T-cell differentiation, development and activation. CD4 is constitutively expressed on the surface of various immune cells, including monocytes, macrophages, eosinophils, dendritic cells, and most prominently T lymphocytes, where it functions as an essential co-receptor and co-ligand for T-cell receptor (TCR) and major histocompatibility complex class II (MHC-II) molecules. Ligation by MHC-II molecules on the surface of antigen-presenting cells can serve to influence adaptive immunity by facilitating helper T-cell activation and macrophage differentiation, while ligation by proinflammatory cytokine IL-16 can contribute to innate immunity by chemoattracting CD4-expressing peripheral immune cells along an IL-16 gradient for their recruitment and activation at sites of inflammation. The protean functionality of CD4 extends past immunity as CD4 also notably serves as the major receptor for HIV-1 and human herpes virus 7 (HHV-7) infections. During HIV pathogenesis, CD4 acts instrumentally as a high-affinity entry receptor for the internalization of HIV-1 following binding of the viral envelope glycoprotein gp120 to CD4's extracellular domain. PeproTech'sCHO cell-derived Recombinant Human sCD4 is amonomeric glycoprotein of 371 amino acid residues, which correspond to the extracellular CD4 domain, and a calculated molecular weight of 41.3 kDa. As a result of glycosylation, Recombinant Human sCD4 migrates with an apparent molecular mass of approximately 45-55 kDa by SDS-Page Gel analysis, under reducing conditions.

Additional Text

Gene ID

920

Gene Name

CD4

Storage Note

Store at 4°C if intended for use within 3 months, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for up to 30 months after the date of receipt when stored at -20°C to -80°C. Upon reconstitution, the antibody can also be stored for 1 week at 2° to 8°C. Please avoid freeze-thaw cycles. Store working aliquots at -20°C to -80°C.

Price

£344.00

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