Human GDF15 Protein (Recombinant)
Catalogue Number: LS-G133786-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Molecular Weight: | 24.6 kDa |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | GDF15, MIC1, MIC-1, NAG-1, NRG-1, NSAID-regulated gene 1 protein, PLAB, NSAID-activated gene 1 protein, Placental TGF-beta, PTGFB, GDF-15, PTGF-beta |
| Host Cell: | CHO Cells |
| Shipping Condition: | RT |
| Unit(s): | 20 ug, 5 ug |
Description
Description: GDF-15 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa.
Additional Text
Gene ID
9518
Gene Name
GDF15
Storage Note
Follow reconstitution with further dilution in a buffer containing a carrier protein. Store working aliquots at -20°C to -80°C. Avoid repeat freeze-thaw cycles.
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