Human Soluble Interleukin 2 Receptor Alpha (sIL2Ra) Protein (Recombinant)
Catalogue Number: LS-G133795-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Molecular Weight: | 24.8 kDa or 40-50 kDa |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Host Cell: | CHO Cells |
| Shipping Condition: | RT |
| Unit(s): | 25 ug, 5 ug |
Description
Description: The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Ra, IL-2Rβ, and IL-2R?. The IL-2Ra is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2Ra releases the entire extracellular domain of IL-2Ra, thereby generating a 219 amino acid soluble protein called soluble IL-2Ra (sIL-2Ra). The homodimeric form binds IL-2 (KD=10mM) and facilitates IL-2 signaling. The secreted sIL-2Ra is expressed on leukemia cells, lymphoma cells, and newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant Human sIL-2 Receptor a is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2Ra. As a result of glycosylation, Recombinant Human sIL-2 Receptor a migrates with an apparent molecular mass of approximately 40-50 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.
Additional Text
Storage Note
Store at -20°C. Protect from moisture.
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations