Human Soluble Interleukin 6 Receptor Alpha (sIL6Ra) Protein (Recombinant)
Catalogue Number: LS-G133797-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Molecular Weight: | 37.9 kDa or 57-70 kDa |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Host Cell: | CHO Cells |
| Shipping Condition: | RT |
| Unit(s): | 20 ug, 5 ug |
Description
Description: IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Ra and gp130. While the IL-6Ra chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Ra. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Ra alone. IL-6Ra is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6Ra, which consists of only the extracellular domain of the IL-6Ra chain, acts as an agonist of IL-6 activity at low concentrations. PeproTech's CHO cell-derived Recombinant Human sIL-6 Receptor a is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6Ra. As a result of glycosylation, Recombinant Human sIL-6 Receptor a migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions.
Additional Text
Storage Note
Store at -20°C. Protect from moisture.
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