Human Soluble Interleukin 4 Receptor Alpha (sIL4Ra) Protein (Recombinant)
Catalogue Number: LS-G133798-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Molecular Weight: | 23.9 kDa or 50-65 kDa |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Host Cell: | CHO Cells |
| Shipping Condition: | RT |
| Unit(s): | 20 ug, 5 ug |
Description
Description: IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (?c). The type I receptor contains, in addition to the ?c, an IL-4Ra subunit, whereas the type II receptor contains the IL-13Ra. The secreted extracellular domain of IL-4Ra, called sIL-4Ra, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naive CD4+ T cells and class switching to IgG1 and IgE. PeproTech's CHO cell-derived Recombinant Human sIL-4 Receptor a is a 23.9 kDa glycoprotein corresponding to 209 amino acid residues of the extracellular domain of IL-4Ra. As a result of glycosylation, Recombinant Human sIL-4 Receptor a migrates with an apparent molecular mass of approximately 50-65 kDa by SDS-PAGE gel, under reducing conditions.
Additional Text
Storage Note
Store at -20°C. Protect from moisture.
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