Human TMIGD2 Protein (Recombinant)
Catalogue Number: LS-G136247-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Molecular Weight: | 40.1kDa |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | TMIGD2, IGPR1, IGPR-1 |
| Host Cell: | CHO Cells |
| Shipping Condition: | RT |
| Unit(s): | 10 ug, 50 ug |
Description
Description: Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2), or CD28H, is a type I costimulatory transmembrane receptor of the CD28 receptor family that functions as both an adhesion molecule and regulator of T cell function. TMIGD2 is constitutively expressed on naive T cells and NK cells, although expression is rapidly lost upon stimulation. Interaction with its ligand, B7-H7/HHLA2, co-stimulates T cell proliferation and differentiation, as well as increases cytokine production through the Akt pathway. TMIGD2 is also widely expressed on cells of epithelial and endothelial origin where it regulates cell morphology and cell-cell interaction, reduces cell migration and promotes angiogenesis. The cytoplasmic tail of TMIGD2 interacts with SH3-containing signaling molecules, such as SPIN90, CACNB2, BPAG1 and MIA, to modulate angiogenesis. CHO cell-derived Recombinant Human TMGID2/CD28H Fc is a glycosylated, disulfide-linked homodimer of 361-amino-acid-residues whose monomer consists of the 128-amino-acid extracellular domain fused to the 231-amino-acid length Fc portion of human IgG1 by two glycine residues. The calculated molecular weight of monomeric Recombinant TMIGD2/CD28H Fc is 40.1kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 55-60 kDa by SDS-PAGE analysis under reducing conditions.
Additional Text
Gene Name
TMIGD2
Gene ID
126259
Storage Note
Before reconstitution: Short term: Room temperature; Long term: -20°C to -80°C. After reconstitution: Short term: 4°C; Long term: Aliquot and store with a carrier protein at -20°C to -80°C. Avoid freeze thaw cycles. Microcentrifuge before opening.
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