Mouse SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89)
Catalogue Number: LS-G27012-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Shelf Life: | 6 months |
| Molecular Weight: | 8 kDa (SDS-PAGE) |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | CXCL12, C-X-C motif chemokine 12, HIRH, IRH, SDF-1, SDF-1b, SDF1A, SDF1B, TPAR1, TLSF-a, TLSF-b, SDF-1a, SDF1, Sdf1alpha, Stromal cell-derived factor 1, TLSF, HSDF-1, PBSF, SCYB12 |
| Host Cell: | CHO Cells |
| Shipping Condition: | RT |
| Unit(s): | 25 ug, 5 ug |
Description
Description: SDF-1 a and SDF-1 Beta, members of the chemokine a subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. SDF-1 a and SDF-1 Beta cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1 a and SDF-1 Beta are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1 Beta and absent from SDF-1 a. SDF-1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF-1/PBSF acts via the chemokine receptor CXCR4 and has been shown to be a chemoattractant for T-lymphocytes, monocytes, pro- and pre-B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 have been found to have impaired B-lymphopoiesis, myelopoiesis, vascular development, cardiogenesis and abnormal neuronal cell migration and patterning in the central nervous system. Recombinant Mouse SDF-1 a/CXCL12 produced in CHO cells is a polypeptide chain containing 68 amino acids. A fully biologically active molecule, rm SDF-1 Beta/CXCL12 has a molecular mass of 8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Additional Text
Gene ID
6387
Gene Name
CXCL12
Storage Note
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 3 months.
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations