Human BAFF / TNFSF13B Protein (Recombinant)

Catalogue Number: LS-G27062-LSP

Manufacturer:	LifeSpan BioSciences Inc.
Shelf Life:	6 months
Molecular Weight:	17 kDa (SDS-PAGE)
Physical state:	Lyophilized
Type:	Other Recombinant Protein
Alias:	TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20
Host Cell:	CHO Cells
Shipping Condition:	Blue Ice
Unit(s):	1 unit, 10 units, 50 units

Overview

Description

Description: B-cell activating factor, also known as BAFF, TALL-1, TNAK, and zTNF4, is a member of the TNF ligand superfamily designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins lacking a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, resting CD4+ T cells, thymus and peripheral blood leukocytes.

Additional Text

Gene ID

10673

Gene Name

TNFSF13B

Storage Note

Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

Price

£2,783.00

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