Human IL18BP Protein (Recombinant)
Catalogue Number: LS-G27228-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Shelf Life: | 6 months |
| Molecular Weight: | 42-44 kDa (SDS-PAGE) |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | IL18BP, IL18BPa, Interleukin-18-binding protein, Interleukin 18 binding protein, Tadekinig-alfa, IL-18BP |
| Host Cell: | CHO Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 unit, 10 units, 50 units |
Description
Description: Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
Additional Text
Gene ID
10068
Gene Name
IL18BP
Storage Note
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.
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