Mouse GDNF Protein (Recombinant)
Catalogue Number: LS-G27230-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Shelf Life: | 6 months |
| Molecular Weight: | 17-22 kDa (SDS-PAGE) |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | GDNF, HSCR3, HFB1-GDNF, ATF, HGDNF |
| Host Cell: | CHO Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 units, 5 units |
Description
Description: Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson's Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
Additional Text
Gene ID
2668
Gene Name
GDNF
Storage Note
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.
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