Human Endostatin Protein (Recombinant)
Catalogue Number: LS-G27307-LSP
| Manufacturer: | LifeSpan BioSciences Inc. |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | COL18A1, Collagen, type XVIII, alpha 1, Collagen alpha-1(XVIII) chain, Endostatin, KNO, KNO1, KS, Multi-functional protein MFP, Antiangiogenic agent, Collagen alpha 1(xviii), Knobloch syndrome, type 1 |
| Host Cell: | Pichia pastoris |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 units |
Description
Description: Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Additional Text
Gene ID
80781
Gene Name
COL18A1
Storage Note
Store Lyophilized at room temperature up to 1 month; Reconstituted for up to 2 weeks at 2°C to 8°C. Aliquot and freeze at -20°C for long term storage. Avoid freeze/thaw cycles.
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