Anti-Human IL-6R (Sarilumab) Dylight® 488
Catalogue Number: LT1711-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | |
| Clone: | Hu137 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, IHC, FA |
Description
Description: IL-6 and its signaling pathway play a part in immune response regulation, inflammation, and hematopoiesis.2 Sarilumab is a research-grade recombinant human monoclonal IL-6 receptor antagonist. It specifically binds to both the transmembrane and soluble forms of the IL-6 receptor, thus inhibiting IL-6-mediated cis and trans-signaling in a dose-dependent manner.1 Therapeutic Sarilumab, also known by the trade name Kevzara, is currently used to treat Rheumatoid Arthritis1, however, as of March 2020, The Feinstein Institute of Northwell Health publicized a study on "a human antibody that may prevent the activity" of IL-6 for the treatment of COVID-19.3 Anti-Human IL-6 (Sarilumab) utilizes the same variable regions from the therapeutic antibody Sarilumab making it ideal for research projects.
Additional Text
Concentration
0.2 mg/ml
Antibody Clonality
Monoclonal, Recombinant Monoclonal
Storage Note
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
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DELIVERY
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