MAdCAM-1 (Mucosal Addressin Cell Adhesion Molecule 1) (PE)

Catalogue Number: M1275-01-PE-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	CA102.2C1
Isotype:	IgG1
Immunogen:	Bacterially expressed human MAdCAM-1.
Application:	WB, FLISA

Overview
Datasheets

Description

Description: Mucosal addressin cell adhesion molecule-1 (MadCAM-1) is a cell-surface immunogloblin (Ig) superfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, a transmembrane domain, and a short cutoplasmic domain. The molecule is similar to ICAM1 and VCAM1. It interacts via its N-terminal Ig domain with the lymphocyte homing receptor alpha4 beta73, which plays a critical role in forming the gut-associated lymphoid system. MAdCAM-1 promotes the adhesion of T and B cells, monocytes/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to the vascular endothelium. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene. The molecular weight is about 43kD, and it is highly expressed on high endothelial venules(VEC) and lamina propia venules found in the small intestine.

Additional Text

Specificity

Recognizes human MAdCAM-1 (mucosal addressin cell adhesion molecule -1). Clone 3H2631 has been reported to block the binding of human cells expressing alpha4 Beta7 to immobilized MAdCAM-1 in vitro.

Purification

Protein A purified

Antibody Clonality

Monoclonal

M1275-01-PE Datasheet

Price

£1,137.00

-

Quantity
Unit Size

Find out about delivery