Anti-Marburg Virus, Glycoprotein (GP1) [MARV-72] - Purified No Carrier Protein

Catalogue Number: M233-LET

Manufacturer:	Leinco Technologies, Inc
Type:	Recombinant Monoclonal
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 250 ug
Host name:
Clone:	MARV-72
Isotype:
Immunogen:
Application:	ELISA, EM, NT

Overview

Description

Description: MARV is a highly pathogenic virus that belongs to the Filoviridae family, along with Ebola virus1. It can cause severe hemorrhagic fever in humans, with mortality rates as high as 90%2. MARV is transmitted to humans through contact with infected animals, such as fruit bats or monkeys, or direct contact with the bodily fluids of infected individuals3. There are currently no approved vaccines or specific treatments for MARV infection. Research has focused on understanding the virus's replication, immune evasion mechanisms, and developing potential vaccines and therapeutics. Animal models, such as nonhuman primates and guinea pigs, have been used to study the virus and evaluate potential interventions. Studies on MARV's envelope GP have shown that the virus can evade antibody-mediated immune pressure through mutations in the furin-cleavage site and deletion of the mucin-like region, demonstrating the GP's structural flexibility and variability4. These findings contribute to our understanding of MARV's life cycle, immune evasion mechanisms, and potential therapeutic approaches. Clone MARV-72 (also known as MR72) is recognized for its wide-ranging reactivity against filoviruses, such as Ebola and Marburg viruses. It is noteworthy for being one of the rare antibodies capable of attaching to GPs of both types of viruses, making it highly sought after for therapeutic applications. MARV-72 has demonstrated its efficacy in neutralizing these viruses and offering protection in non-human primate models5.

Additional Text

Purification

Purified

Concentration

1 mg/ml

Antibody Clonality

Monoclonal, Recombinant Monoclonal

Storage Note

This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.

Price

£332.00

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