MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38) (Agarose)

Catalogue Number: M2352-05B-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in cell lysis buffer, supplemented with 100 ug/ml BSA and 50% glycerol.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	400 ul
Host name:	Mouse
Clone:	3i19
Isotype:	IgG1
Immunogen:	Synthetic phospho-peptide corresponding to residues around Thr180/Tyr182 of human p38 MAP kinase.
Application:	IP

Overview
Datasheets

Description

Description: p38 MAP kinase (MAPK), also called RK (3) or CSBP (2), is the mammalian homologue of the yeast HOG kinase and participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-5). MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr180 and Tyr182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6) and MEF2 (5-8).

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Binds only p38 MAP kinase activated by phosphorylation at Thr180/Tyr182.

Modification

Phosphorylated, Thr180

Antibody Clonality

Monoclonal

M2352-05B Datasheet

Price

£741.00

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Quantity
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