MDR1 (Multi Drug Resistance Protein 1, ABC20, ATP Binding Cassette Subfamily B (MDR/TAP) Member 1, ABCB1, CD243, CLCS, GP170, P-Glycoprotein, P-gp, P Glycoprotein 1, PGY1) (FITC)

Catalogue Number: M2825-15F-FITC-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with fluorescein isothiocyanate (FITC).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	UIC2
Isotype:	IgG2a
Immunogen:	Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA.
Application:	FC, IF, IP, IHC

Overview
Datasheets

Description

Description: CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein), a transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, which acts as an active efflux pump for a diverse range of lipophillic compounds.CD243 is expressed at low levels in the cell membrane of peripheral blood leukocytes, and constitutively expressed on the apical plasma membrane of excretory epithelial cells of the kidney, liver, brain and small intestine. CD243 mediates resistance to many chemotherapeutic agents used for tumor suppression and is therefore of special interest to oncologists. M2825-15F is a strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs. Can be used in a shift assay to selectively demonstrate the expression and functional activity of CD243 in a target cell.

Additional Text

Gene Name

ABCB1

Gene ID

5243

Uniprot ID

P08183

Specificity

Recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein). Species Crossreactivity: primate. Does not cross-react with mitochondrial pyruvate carboxylase, mouse, rat.

Purification

Protein A purified

Antibody Clonality

Monoclonal

M2825-15F-FITC Datasheet

Price

£799.00

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