Myelin Basic Protein, aa82-87 (MBP)
Catalogue Number: M9758-03D-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in 0.09% sodium azide. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 ml |
| Host name: | Rat |
| Clone: | 2Q292 |
| Isotype: | IgG |
| Immunogen: | Bovine myelin basic protein. |
| Application: | ELISA, WB, RIA, IHC |
Description
Description: Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles (3). MBP serves as a marker for oligodendrocytes and Schwann cells (3). MBP is also a marker for malignant schwannomas (4) and appears to play a significant role in the etiology of multiple sclerosis (5-7) and experimental autoimmune encephalomyelitis (8).
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Reacts with intact MBP and synthetic peptide aa82-99. Reacts weakly with peptides ending in the phe 91 where the 91-92 phe-phe bond is broken. Epitope: Mapped to the region DENPVV. Species crossreactivity: Human, bovine, sheep, rabbit, mouse and rat.
Purification
Supernatant
Antibody Clonality
Monoclonal
M9758-03D Datasheet
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