Mouse anti MUC1 (CD227)

Catalogue Number: MUB1206P-NMB

Manufacturer:	Nordic MuBio
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	RT
Unit(s):	0.1 mg
Host name:	Mouse
Clone:	139H2
Isotype:	IgG1
Immunogen:
Application:	ELISA, FC, IF, IP, EM, WB, IHC-Fr

Overview

Description

Description: Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in Humans. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs.The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.

Additional Text

Gene Name

MUC1

Gene ID

4582

Uniprot ID

P15941

Antibody Clonality

Monoclonal

Storage Note

The antibody is shipped at ambient temperature and may be stored at +4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at +4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.

Application Notes

Antibody 139H2 is useful for ELISA, immunofluorescence, flow cytometry, immunoprecipitation, western blot, electron microscopy and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration.

Price

£359.00

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