IU1
Catalogue Number: N-1197-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | HFIP |
| Type: | Protease Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 10 mg |
Description
Description: Selective inhibitor of Usp14 (IC50<4 µM). Enhances proteasome activity and substrate proteolysis1,2. Inhibits Dengue virus replication3. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load4. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model5. Cell permeable.
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