Coronavirus COVID-19 Recombinant SARS-Cov-2 Nucleocapsid protein, His-tagged
Catalogue Number: N-196V-CRE
| Manufacturer: | Creative BioMart |
| Shelf Life: | 12 months |
| Molecular Weight: | 47.08 KDa |
| Type: | Other Recombinant Protein |
| Host Cell: | Baculovirus-Insect cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 ug |
Description
Description: Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
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