P7C3
Catalogue Number: N-3004-2-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Biochemicals |
| Shipping Condition: | RT |
| Unit(s): | 25 mg |
Description
Description: P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity1. Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis2. Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease3. Restores hippocampal neurogenesis in a mouse model of Down Syndrome4. The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD5. Active in vivo.
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