Tolcapone
Catalogue Number: N-3007-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Enzyme Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 10 mg |
Description
Description: Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes1. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity2. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo3. Inhibits O-methylation of exogenous polyphenols such as EGCG4. Cell permeable. Orally bioavailable.
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