SB-225022
Catalogue Number: N-3016-2-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Other Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 25 mg |
Description
Description: Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors1. Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe2. Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence3 and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages4. Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation5.
SUPPORT
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PRODUCT
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DELIVERY
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