DAPT
Catalogue Number: N-3018-2-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Protease Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 25 mg |
Description
Description: Inhibitor of gamma-secretase (IC50 in human primary neurons = 115 nM for total amyloid beta or 200 nM for Amyloid Beta 42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Amyloid Beta in brain extract, cerebrospinal fluid and plasma from mice and rats.2,3 DAPT blocks Notch signaling which promotes neuronal differentiation of precursor cells.4 Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.
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