ANA-12
Catalogue Number: N-3031-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Kinase Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 5 mg |
Description
Description: TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 µM for the high and low affinity sites respectively. Systemic administration to adult mice decreased TrkB activity in the brain without affecting neuronal survival or altering TrkA and TrkC functions. Displays antidepressant and anxiolytic properties in mouse models after systemic administration. Has been used to elucidate the role of BDNF in food intake, in improvement of cognitive decline during calorie restriction and in the discovery of new neurotrophic agents.
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