Bexarotene
Catalogue Number: N-3032-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Biochemicals |
| Shipping Condition: | RT |
| Unit(s): | 10 mg |
Description
Description: A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRalpha, beta, gamma respectively)1. Clinically useful antineoplastic agent for cutaneous T-cell lymphoma2 Causes complete regression of mammary carcinoma3. Bexarotene significantly increases clearance of soluble B-amyloid in a mouse Alzheimer's model and increases cognitive ability4. Reverses apoE4-driven brain pathology and behavioral deficitsin vivo5.
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