Nectin-2 (Poliovirus Receptor-related Protein 2, Herpes Virus Entry Mediator B, Herpes virus Entry Mediator B, HveB, Murine Herpes Virus Entry Protein B, mHveB, Poliovirus Receptor Homolog, CD112, Pvrl2, Mph, Pvr, Pvs) (FITC)
Catalogue Number: N0571-50C1-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rat |
| Clone: | 13A61 (502-57) |
| Isotype: | IgG2a |
| Immunogen: | Extracellular domain of mouse nectin-2 |
| Application: | ELISA, IF, IP, WB, IHC, FLISA |
Description
Description: Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice.
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Recognizes mouse Nectin-2. Species Crossreactivity: human
Purification
Protein G purified
Antibody Clonality
Monoclonal
N0571-50C1 Datasheet
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