Sheep anti Human Rhombotin 2
Catalogue Number: N105P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | LIM domain only protein; cysteine-rich protein TTG-2; T-cell translocation protein 2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Full length rhombotin 2 protein |
| Application: | WB |
Description
Description: Two homologues of the rhombotin gene have now been isolated. One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene. Human and mouse Rhom-2 are highly conserved and, like rhombotin, encode two tandem cysteine-rich LIM domains. Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus. The Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors. Chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved.
Additional Text
Uniprot ID
P25791
Gene ID
4005
Gene Name
LMO2
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Western Blots at 1-10 ug /ml
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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