Mouse anti Human Rb (Retinoblastoma)
Catalogue Number: N120M-EXA
| Manufacturer: | ExAlpha |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Retinoblastoma-associated protein; pRb; pp110; p105-Rb |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | XZ104 |
| Isotype: | IgG1 |
| Immunogen: | A recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence |
| Application: | IP |
Description
Description: The immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.
Additional Text
Gene ID
5925
Gene Name
RB1
Uniprot ID
P06400
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
Applications: Immunoprecipitation (not recommended for Western blotting or immunohistochemistry).
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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