Mouse anti Human Rb (Retinoblastoma)
Catalogue Number: N130M-EXA
| Manufacturer: | ExAlpha |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Retinoblastoma-associated protein; pRb; pp110; p105-Rb |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | C36 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | IP |
Description
Description: Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.
Additional Text
Gene ID
5925
Gene Name
RB1
Uniprot ID
P06400
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
Applications: Immunoprecipitation
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
SUPPORT
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DELIVERY
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