Nerve Growth Factor Receptor, p75 (NGFR, NGF Receptor, CD271, Gp80 LNGFR, p75 ICD, p75 Neurotrophin, p75 NTR, Tumor Necrosis Factor Receptor Superfamily Member 16, TNFR Superfamily Member 16, TNFRSF16) (ATTO 488)

Catalogue Number: N2050-11N-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 10mM Tris, 50mM sodium chloride. Labeled with ATTO 488.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CD271\|Gp80-LNGFR\|low affinity neurotrophin receptor p75NTR\|low-affinity nerve growth factor receptor\|NGF receptor\|p75 ICD\|p75(NTR)\|p75NTR\|TNFR superfamily, member 16\|TNFRSF16\|tumor necrosis factor receptor superfamily member 16
Shipping Condition:	Blue Ice
Unit(s):	50 ug
Host name:	Mouse
Clone:	9G390
Isotype:	IgG2a
Immunogen:	Human WM245 melanoma cells.
Application:	FC, IF, IHC, FLISA

Overview
Datasheets

Description

Description: Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF; 113505), neurotrophin-3 (NTF3; 162660), and neurotrophin-4/5 (NTF5; 162662). At the time of its discovery, NGFR was considered a unique type of protein. Subsequently, however, a large superfamily of tumor necrosis factor receptors were found to share the overall structure of NGFR (4 extracellular ligand-binding, cysteine-rich repeats, or CRs, and signaling through association with, or disassociation from, cytoplasmic interactors). The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB; see 164011) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1; 191315), TRKB (NTRK2; 600456), and TRKC (NTRK3; 191316). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF5 and BDNF, and NTF3, respectively (Ip et al., 1993). NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. Produced in P75 knock-out mouse.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

NGFR

Gene ID

4804

Uniprot ID

P08138

Specificity

Recognizes human p75NTR (low affinity neurotrophin receptor). Species Crossreactivity: rat, feline, canine, porcine, rabbit and sheep. Does not react with mouse.

Purification

Affinity Purified

Antibody Clonality

Monoclonal

N2050-11N Datasheet

Price

£581.00

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Quantity
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