NMDA 1 Receptor (NMDA R1, N-methyl-D-aspartate) (MaxLight 490)
Catalogue Number: N2904-35-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 2Q187 (54.1) |
| Isotype: | IgG2a |
| Immunogen: | Recombinant fusion protein containing GST and NMDAR1 (aa 660-811). Epitope: extracellular loop between transmembrane regions III and IV. |
| Application: | ICC, RIA, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl- 4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience. They are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors appear to be a target for ethanol at physiological concentrations which may play a significant role in alcoholism.
Additional Text
Gene Name
GRIN1
Gene ID
2902
Uniprot ID
Q05586
Specificity
Recognizes an epitope between amino acids 660-811 of the human NMDAR1 receptor. Shows no crossreactivity with NMDAR2, NMDAR3, NMDAR4 or NMDAR5. Species Crossreactivity: rat, monkey and Xenopus.
Accession Number
NM_000832.5
Purification
Protein A purified
Antibody Clonality
Monoclonal
N2904-35-ML490 Datasheet
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