NOTCH 1 (Neurogenic Locus Notch Homolog Protein 1, Motch A, mT14, p300, Motch, Notch1) (MaxLight 490)
Catalogue Number: N5375-03P-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | mN1A |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to cdc10-NCR region within mouse Notch1. |
| Application: | FC, WB, IHC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Notch1, a single transmembrane receptor which is expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has suggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis. Following ligand binding, Notch1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression.
Additional Text
Gene Name
NOTCH1
Uniprot ID
Q01705
Gene ID
18128
Specificity
Recognizes mouse NOTCH 1. Species Crossreactivity: human.
Purification
Protein G purified
Antibody Clonality
Monoclonal
N5375-03P-ML490 Datasheet
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