Human Noggin Protein (NOG-HM001)
Catalogue Number: NOG-HM001-KAT
NOG-HM001 Image
NOG-HM001 Image
NOG-HM001 Image
NOG-HM001 Image
The purity of Human Noggin is greater than 95% as determined by SEC-HPLC.
NOG-HM001 Image
Human Noggin on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
NOG-HM001 Image
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50-for this effect is-4-80 ng/mL in the presence of 50 ng/mL of recombinant Human BMP-4.
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 23.05 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | Noggin; NOG; SYM1; SYNS1 |
| Host Cell: | CHO Cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | WB |
Description
Description: Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β-catenin, EGFR, ERK and Akt.
Additional Text
Gene Name
NOG
Gene ID
9241
Uniprot ID
Q13253
Protein Tag
Untagged
Short Description
Recombinant Human Noggin Protein is expressed from CHO without tag.It contains Gln28-Cys232.
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 0.05 EU per µg by the LAL method.
NOG-HM001 Datasheet
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