GRP78 antibody
Catalogue Number: ORB151299-BOR
| Manufacturer: | Biorbyt |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | |
| Immunogen: | Rat GRP78 (Bip) synthetic peptide conjugated to KLH |
| Application: | ICC, IF, IP, WB, IHC |
Additional Text
Molecular Weight
78kDa
Gene Name
HSPA5
Concentration
1 mg/ml
Uniprot ID
P06761
Gene ID
25617
Note
For research use only.
Antibody Clonality
Polyclonal
Storage Note
-20°C
Specificity
78 kDa glucose regulated protein antibody, 78 kDa glucose-regulated protein antibody, AL022860 antibody, AU019543 antibody, BIP antibody, D2Wsu141e antibody, D2Wsu17e antibody, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody, Endoplasmic reticulum lumenal antibody, Ca2+ binding protein grp78 antibody, FLJ26106 antibody, Glucose Regulated Protein 78kDa antibody, GRP 78 antibody, GRP-78 antibody, GRP78_HUMAN antibody, Heat shock 70 kDa protein 5 antibody, Heat Shock 70kDa Protein 5 antibody, HSCe70 antibody, HSPA 5 antibody, HSPA5 antibody, Immunoglobulin Heavy Chain Binding Protein antibody, Immunoglobulin heavy chain-binding protein antibody, mBiP antibody, MIF2 antibody, Sez7 antibody
Short Description
Rabbit polyclonal to GRP78 (ATTO-390). GRP78 is a ubiquitously expressed, 78-kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress, and its protein levels are reduced in the brains of Alzheimers patients. Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs .
ORB151299 Datasheet
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