Catalogue Number: ORB151336-BOR
Manufacturer: | Biorbyt |
Type: | Polyclonal Primary Antibody - Conjugated |
Alias: | Lys Asp Glu Leu Antibody |
Shipping Condition: | Blue Ice |
Storage Condition: | 2-8°C |
Unit(s): | 200 ug |
Host name: | Rabbit |
Clone: | |
Isotype: | |
Immunogen: | KDEL containing peptide immunogen |
Application: | ICC, IF, WB, IHC |
1 mg/ml
For research use only.
Polyclonal
-20°C
Rabbit polyclonal to KDEL (ATTO-594). The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER.