Human IgG Fc protein

Catalogue Number: ORB257567-BOR

Manufacturer:	Biorbyt
Molecular Weight:	25.7 kDa
Type:	Immunoglobulins
Alias:	IGHG2
Host Cell:	HEK293 cells
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 200 ug
Application:	SDS-PAGE

Overview
Datasheets

Additional Text

Protein Tag

Untagged

Note

For research use only.

Storage Note

-20°C

Application Notes

Tag FreeExperiment Notes: This protein carries no "tag". The protein has a calculated MW of 25.7 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Short Description

Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis. Ig gamma-2 chain Fc region contains two constant regions of IgG2 H chain (CH2, CH3).

ORB257567 Datasheet

Price

£801.00

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