p53 (Tumor Suppressor Protein, Oncogene Protein) (MaxLight 550)

Catalogue Number: P1001-26D1-ML550-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with MaxLight™550.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	antigen NY-CO-13\|BCC7\|BMFS5\|cellular tumor antigen p53\|LFS1\|mutant tumor protein 53\|P53\|p53 tumor suppressor\|phosphoprotein p53\|transformation-related protein 53\|TRP53\|tumor protein 53\|tumor supressor p53
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	PAB240
Isotype:	IgG1, kappa
Immunogen:
Application:	ICC, IP, WB, IHC

Overview
Datasheets

Description

Description: P53 is a 339 amino acid protein (53kD) that is thought to act as a tumor suppressor gene. p53 is a DNA-binding protein, and missense mutation of the gene can lead to loss of its DNA-binding functions, and subsequent inactivation of p53 may be a contributing factor in tumorigenesis. Mutation of p53 occurs at many sites and represents a common genetic alteration in human malignancy. Mutations which result in overexpression of p53 can be detected by immunohistochemistry, and overexpression and accumulation of p53 in cell nucleus was reported for a number of human tumors, such as breast, lung and colon carcinomas. Staining of p53 overexpression may be a useful tumor and prognostic marker.

Additional Text

Gene Name

TP53

Gene ID

7157

Uniprot ID

P04637

Specificity

Reacts with mutant p53 and denatured wild-type p53(1). Reactivity has been shown with most mammalian species, including; human, rat and mouse. The epitope is located between the evolutionally conserved Box III and IV regions (approximately 161–220aa in the human sequence). Reactivity with a 75kD cytoplasmic protein has been reported.

Purification

Purified

Antibody Clonality

Monoclonal

P1001-26D1-ML550 Datasheet

Price

£979.00

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Quantity
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