p53 (Tumor Protein p53, Tumor Suppressor p53, TP53, TRP53, Cellular Tumor Antigen p53, Phosphoprotein p53, Antigen NY-CO-13, LFS1) (PE)

Catalogue Number: P1001-26R-PE-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	antigen NY-CO-13\|BCC7\|BMFS5\|cellular tumor antigen p53\|LFS1\|mutant tumor protein 53\|P53\|p53 tumor suppressor\|phosphoprotein p53\|transformation-related protein 53\|TRP53\|tumor protein 53\|tumor supressor p53
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	DO-1
Isotype:	IgG2a
Immunogen:	Recombinant protein corresponding to human p53.
Application:	ELISA, IP, WB, IHC

Overview
Datasheets

Description

Description: p53 is a 53kD protein that forms tetramers and functions as a tumor suppressor and transcriptional activator of genes that inhibit growth and/or invasion, cell cycle checkpoint after irradiation, DNA repair, apoptotic induction, signal transduction, and cell adhesion. This protein is localized to the nucleus when activated and can be upregulated by genotoxic or other cellular stresses. p53 is modified by phosphorylation, acetylation, ribosylation, ubiquitination, and sumoylation; ubiquination targets p53 for degradation via mdm2. This protein interacts with a variety of proteins including mdm2, mdmx, topoisomerase I, PML3, Bcl-XL, Bcl-2, Chk1, JNK, p38, HIPK2, CK2, DNA-PK, p300/CBP, PCAF, PARP1, and HDAC1-3. Mutant p53 associates with p63 and p73.

Additional Text

Gene Name

TP53

Gene ID

7157

Uniprot ID

P04637

Specificity

Recognizes the human p53 tumor suppressor protein, binding to both wild type and mutant forms. Rcognizes an epitope at the N-terminal end of p53 between amino acids 20-25. Species Crossreactivity: Bovine, equine and feline (2). Does not react with mouse or rat.

Purification

Protein G purified

Antibody Clonality

Monoclonal

P1001-26R-PE Datasheet

Price

£839.00

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