P2X7 Receptor (P2X Purinoceptor 7, P2rx7, P2X7, P2X(7), P2X7R, AI467586, ATP Receptor, P2Z Receptor, Purinergic Receptor) (MaxLight 490)
Catalogue Number: P1003-15E-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | AI467586|ATP receptor|P2X purinoceptor 7|P2X(7)|P2X7 purinoceptor|P2X7 receptor|P2X7R|P2Z receptor |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rat |
| Clone: | Hano43 |
| Isotype: | IgG2b |
| Immunogen: | A P2X7-expression construct and a final boost with P2X7-transfected HEK cells. |
| Application: | IF |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Purinoceptor 7 is also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Additional Text
Gene Name
P2RX7
Uniprot ID
Q9Z1M0
Specificity
Recognizes mouse P2X purinoceptor 7.
Purification
Protein G purified
Gene ID
18439
Antibody Clonality
Monoclonal
P1003-15E-ML490 Datasheet
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