PAEL Receptor (GPR37, PAELR, G-protein Coupled Receptor 37, ETBR-LP-1, Endothelin B Receptor-like Protein 1, Parkin-associated Endothelin Receptor-like Receptor)
Catalogue Number: P1799-01B-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | EDNRBL|endothelin B receptor-like protein 1|ETBR-LP-1|G protein-coupled receptor 37 (endothelin receptor type B-like)|hET(B)R-LP|PAELR|Parkin-associated endothelin receptor-like receptor|probable G-protein coupled receptor 37|prosaposin receptor GPR37 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 8B38 |
| Isotype: | IgG2a |
| Immunogen: | NS0-derived transfected with human PAEL Receptor corresponding to amino acids Ala27-Cys613. |
| Application: | FC |
Description
Description: GPR37 (G-protein coupled receptor 37), also called ETBR-LP-1 (endothelin B receptor-like protein 1) or PAELR (Parkin-associated endothelin receptor-like receptor) is a 613aa, ~55kD orphan 7-transmembrane receptor. It is mainly expressed in neuronal cells, particularly in cerebellar Purkinje cells and the hippocampus. It is a substrate of the E3 ubiquitin ligase, parkin, which is upregulated during endoplasmic reticulum stress. In a juvenile form of Parkinson's disease, GPR37 accumulates, contributing to stress-induced neuronal cell death. The extracellular portions of human and mouse GPR37 share 68% aa identity.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene Name
GPR37
Gene ID
2861
Uniprot ID
O15354
Specificity
Recognizes human GPR37 transfected cells but not irrelevant transfectants.
Purification
Protein A purified
Antibody Clonality
Monoclonal
P1799-01B Datasheet
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