Sheep anti Human Protein Phosphatase 4 R1 (X/A)
Catalogue Number: P210P-EXA
| Manufacturer: | ExAlpha |
| Type: | Primary Antibody |
| Alias: | Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1; Protein Phosphatase X/A'2; PP4R1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Sheep |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Antibody raised against synthetic peptide corresponding to amino acids 38 to 52 of the human protein phosphatase 4R1. |
| Application: | WB |
Description
Description: Protein serine/threonine phosphatase 4R1 is a protein which is associated with the catalytic subunit of protein serine/threonine phosphatase 4 (PP4C) and may possibly regulate the activity of the enzyme. PP4C is 65% identical to PP2AC at the amino acid level and has been placed in the type 2A family of phosphatases. PP4C has been highly conserved between species sharing 91% amino acid identity between human and Drosophila PP4C is predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. Additionally, PP4C was demonstrated to be an essential enzyme in the development of Drosophila embryos. The expression of PP4C was reduced to 25% of the normal protein level in a mutant strain of Drosophila termed centrosomes minus microtubules (cmm). An interesting characteristic of the cmm phenotype is the presence of regions of cells that are unable to complete mitosis because no microtubules exist to connect chromatin and centrosomes. This phenotype implicates PP4C in the regulation of the nucleation and/or stabilization of microtubules. These data taken together indicate that PP4 has a crucial cellular function, although a physiological substrate for PP4 has not yet been identified.
Additional Text
Gene ID
9989
Gene Name
PPP4R1
Uniprot ID
Q8TF05
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Detects protein phosphatase X/A (PP4 R1) protein by Western blot (5-10 µg/ml). Detects a 125 kDa band in bovine testes lysate. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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