PAR1 (Proteinase Activated Receptor1) (MaxLight 550)

Catalogue Number: P3105-60-ML550-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with MaxLight™550.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	3G232
Isotype:	IgG1
Immunogen:	Synthetic peptide corresponding to the N-terminal region of the human thrombin receptor PAR1.
Application:	FC, ICC, IF, FLISA

Overview
Datasheets

Description

Description: Serine proteases comprise a large family of enzymes that are characterized by a uniquely reactive Ser side chain. They are ubiquitous in prokaryotes and eukaryotes and serve important and diverse biological functions. Although serine proteases are usually considered to act principally as degradative enzymes, certain proteases are signaling molecules that specifically regulate cells by cleaving and triggering members of a new family of Proteinase Activated Receptors (PARs). There are three members of this family, PAR-1 and PAR-3, which are receptors for thrombin, and PAR-2, a receptor for trypsin and mast cell tryptase. Proteases cleave within the extracellular NH2-terminus of their receptors to expose a new NH2-terminus. In common with many G protein-coupled receptors, PARs couple to multiple G proteins and thereby activate many parallel mechanisms of signal transduction. PARs are expressed in multiple tissues by a wide variety of cells, where they are involved on several pathophysiological processes, including growth and development, mitogenesis, and inflammation.

Additional Text

Specificity

Recognizes the cleaved and intact forms of human thrombin receptor PAR1, N-terminus. Does not crossreact with PAR2. Has been shown to completely inhibit the cleavage and activation of PAR1 by thrombin when used in combination with a second PAR1-directed antibody.

Purification

Protein A purified

Antibody Clonality

Monoclonal

P3105-60-ML550 Datasheet

Price

£992.00

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