Parathyroid Hormone, NT, aa1-34 (PTH) (APC)
Catalogue Number: P3109-07-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 8.BG.10 (3H9) |
| Isotype: | IgG2b |
| Immunogen: | Synthetic peptide corresponding to aa1-34 of mature human PTH, conjugated to a carrier protein. |
| Application: | RIA, IHC, FLISA |
Description
Description: Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. Its action is opposed by calcitonin. Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body. PTH half-life is approximately 4 minutes.
Additional Text
Specificity
Recognizes human 1-34 and 1-84 PTH. Has not been cross-adsorbed and may crossreact with homologous proteins from related species.
Purification
Protein G purified
Antibody Clonality
Monoclonal
P3109-07-APC Datasheet
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